To minimize the potential for fatigue, you should:

Taking frequent rest breaks during a long trip can help reduce fatigue. Stimulants, such as caffeine, can ultimately increase the danger of fatigue because you may become extremely tired when they begin to wear off. Wind, rain, snow, and other elements can also increase levels of fatigue, so dress warmly (as needed) and invest in a windshield, especially if you plan to ride long distances.
DMV Writen Test Logo