Who may operate a vehicle that is transporting hazardous materials? Do you currently have motorcycle insurance? Insurance is mandatory to drive in Ohio Yes I have insurance. But please show me your best quotes. No, please help me find the best insurance. Question Who may operate a vehicle that is transporting hazardous materials? Answers Any driver with a CDL A driver with a hazardous materials endorsement A driver with a minimum of 10 years of experience Explanation Only a driver with a hazardous materials endorsement on their CDL may operate a vehicle carrying hazardous cargo.