To obtain a CDL for interstate commerce, an applicant must be at least: Do you currently have motorcycle insurance? Insurance is mandatory to drive in Ohio Yes I have insurance. But please show me your best quotes. No, please help me find the best insurance. Question To obtain a CDL for interstate commerce, an applicant must be at least: Answers 15 years old. 18 years old. 21 years old. 25 years old. Explanation You must be at least 21 years old and have at least one year of driving experience to be licensed to drive in interstate commerce or to transport hazardous materials.