To operate a commercial motor vehicle in interstate commerce, a driver must be at least: Do you currently have motorcycle insurance? Insurance is mandatory to drive in Ohio Yes I have insurance. But please show me your best quotes. No, please help me find the best insurance. Question To operate a commercial motor vehicle in interstate commerce, a driver must be at least: Answers 18 years old. 21 years old. 25 years old. Explanation In Vermont, you must be at least 18 years old to obtain a CDL. To be licensed to operate in interstate commerce, you must be at least 21 years old.