To obtain a CDL for interstate commerce, an applicant must be at least: Do you currently have car insurance? Insurance is mandatory to drive in Ohio Yes I have insurance. But please show me your best quotes. No, please help me find the best insurance. Question To obtain a CDL for interstate commerce, an applicant must be at least: Answers 15 years old. 18 years old. 21 years old. 25 years old. Explanation You must be at least 21 years old to operate a motor vehicle involved in interstate commerce.